In Baby, It's You, filmmaker Anne Makepeace takes us on an intimate journey through the Kafkaesque world of fertility clinics, into the home of lesbian parents, to Christmas among Utah polygamists and New England Puritans, to her brother’s Appalachian goat farm, and on a time trip back to the dark age of illegal abortion. Linking these stories is the bond of family. The characters are the filmmaker, her husband, and their brothers and sisters, all baby-boomers in their forties. The documentary looks at the unconventional ways they are all belatedly creating families of their own. Woven throughout the program is the story of Makepeace and her husband's attempts to conceive a child through intensive fertility procedures, and the emotional roller coaster of anticipation, disappointment, and hope that carries them along.